MSS858: POSTOPERATIVE MANAGEMENT STRATEGIES FOR PATIENTS WITH LOW-GRADE APPENDICEAL MUCINOUS NEOPLASM (LAMN)
James R Faraci, DO, MPH; Eisenhower Army Medical Center
INTRODUCTION: Low-grade appendiceal mucinous neoplasm (LAMN) are a non-invasive subset of appendix neoplasms that are defined by their low-grade epithelial features in the absence of invasive growth. They are a relatively uncommon finding, affecting approximately 6 in 1,000,000 people, and found in approximately 1% of all interval appendectomy specimens. LAMNs themselves can be relatively benign in nature, with most considered to be cured by resection when the mucinous product is confined to the appendix itself. However, if the mucin is spilled during the extraction or found to be extraluminal during the resection, there is a moderate risk of pseudomyxoma peritonei in this subset of patients.
OBJECTIVES: Thus, the question becomes what optimal management strategy is if it is unknown whether there was a potential seeding event during the resection or extraction of an interval appendectomy specimen. Thus, there is a need for further elucidation of the various management strategies cited within the literature.
METHODS: A comprehensive literature review was performed using Google Schoolar, PubMed, MEDLINE, and Cochrane Library databases. Search terms include “Low-grade appendiceal mucinous neoplasm, “LAMN”, “LAMN management”, LAMN Surveillance”, “LAMN Cytoreductive surgery” and “LAMN HIPEC”. Exclusion criteria included case studies or case series, as well as studies focused solely on HAMN and/or appendiceal adenocarcinoma.
DISCUSSION: Many believe that interval appendectomy, even without prior knowledge or workup of mucinous component, is curative in nature and there is no role for additional surveillance or treatment after discovery of a LAMN within the appendiceal specimen. However, in the increase incidence of LAMN within pathological specimen, the treatment of, and post-operative management of LAMNs has become increasingly controversial. There is another school of thought that patients following into the category of status-post appendectomy in the setting of no prior knowledge of presence of LAMN should be cautiously grouped with and treated the same as individuals with localized disease or the presence of acellular mucin on the serosa. This would include a regular surveillance interval and a low threshold for extended resection. Lastly, there may be a role for evaluation for cytoreductive surgery and in some extreme instance, HIPEC. Future directions and alternatives to the current management strategies will also be discussed and reviewed.
CONCLUSION: Standardization of management strategies for low-grade appendiceal mucinous neoplasms is essential for the long-term risk reduction of seeding of the abdomen and development of pseudomyxoma peritonei.